MADRAS VETERINARY COLLEGE

DEPARTMENT OF VETERINARY PHARMACOLOGY AND TOXICOLOGY

Genesis

The Department of Veterinary Pharmacology and Toxicology was one of the earliest departments of the college. The department was established for teaching of materia medica and pharmacy. This department started to offer postgraduate degree programmes in the year 1956. To date, 119 students have completed M.V.Sc and 35 students have completed Ph.D. from this department.

Education

List of courses offered in B.V.Sc & A.H. - Veterinary Pharmacology and Toxicology

Unit 1 – General Pharmacology
Unit 2 – Drugs acting on Autonomic system
Unit 3 – Drugs acting CNS System
Unit 4- Drugs acting on different body systems
Unit 5- Veterinary Chemotherapy
Unit 6- Veterinary Toxicology

PG Education

This department offers M.V.Sc. and Ph.D. Degree Prgrammes in Veterinary Pharmacology and Toxicology

Facilities Available

UG Laboratory

The students are provided hands-on training in compounding of various pharmaceutical preparations and the detection of toxic metals / non-metals/plants in biological samples. Computer aided simulated animal experiments are used to demonstrate the effect of action of various drugs on different body systems. Experiments on antibacterial chemotherapy and toxicological diagnosis are also demonstrated. They are also exposed to various dosage forms of drugs. The department has following UG laboratories (2230 sq. ft.) to handle UG practical classes as per VCI norms.

Experimental Pharmacology Lab
Pharmacy Lab
Toxicology and Chemotherapy Lab

Research facilities

Basic bacteriology (ABST / MIC)
Analytical methods such as spectrophotometry, HPLC, GC
Cell culture facilities
In vitro testing
Extraction and separation of natural products

Research

Research Projects Completed

Sl. No.	Name of the project	Funding Agency	Budget (Rs.)
1	Active Immunization against Somatostatin for growth in broiler chicken	Godrej	10 lakhs
2	Part II scheme on Indigenous drugs in veterinary practice	TN state Government project	80,000
3	Anti-inflammatory activity of Nimesulide in rats	Indian Immunologicals Ltd. Hyderabad	25,000
4	Strengthening of infrastructure for post graduate teaching and research	Department of Science and Technology, Government of India	25 lakhs
5	Development of Standardized Herbal Product for Bovine Mastitis	Department of Biotechnology, Government of India	16.30 lakhs
6	Pharmacokinetics and bioequivalence of oral Enrofloxacin in chicken	M/s Ranbaxy Fine Chemicals, Ltd., New Delhi	1.03 lakhs
7	Bioavailability of in- water formulation of Enrofloxacin in broilers	M/s Suguna Poultry Farm Pvt. Ltd., Coimbatore	1.46 lakhs
8	Isolation and Characterization of Safer and Potent Antiviral Components from Few Potential Medicinal Plants to Effectively Treat and Control Infections of Human Herpes Virus-1 (Herpes Simples Virus-1), Human Herpes Virus-2 (Herpes Simples Virus-2), Human Herpes Virus-3 (Varicella Zoster Virus) By In Vitro And In Vivo Studies	Department of Science and Technology, Government of India	13.2 lakhs
9	A search for natural acaricides from traditional practices in Tamil Nadu	TANUVAS Sub- project	20,000

Research Projects Ongoing

Sl. No.	Name of the project	Funding Agency	Budget (Rs.)
1	Outreach Programme on “Monitoring of Drug Residues and Environmental Pollutants”	Indian Council of Agricultural Research	31.51 lakhs
2	Validation of the Pharmacological Efficacy of Nandhi Mezhugu pretreatment with Kummati Mezhugu in Preclinical models of anovulation and its application in Veterinary medicine in Ovulatory Disorders in Cattle	Ministry of AYUSH	63.42 lakhs
3	Validation of the safety and therapeutic efficacy of Poorna chandirodayam in Dimethylhydrazine dihydrochloride induced colon cancer in rats.	Ministry of AYUSH	65.28 lakhs

Achievements

1. Developed following four B.V.Sc & A.H. courses E-learning modules as per VCI pattern

VPT311 - General and Systemic Veterinary Pharmacology
VPT321 – Veterinary Neuropharmacology
VPT411 – Veterinary Chemotherapy
VPT421 – Veterinary Toxicology

2. Standardized the HPLC based analytical techniques for the analysis of following antimicrobials in chicken meat / chicken egg / chicken plasma / milk

Chicken plasma	Chicken egg	Chicken meat	Bovine milk
Ofloxacin, Sparfloxacin, Levofloxacin, Oxytetracycline, Doxycycline, Tigecycline, Tylosin, Tilmicosin and Tiamulin	Enrofloxacin and Oxytetracycline	Enrofloxacin, Oxytetracycline, Levofloxacin, Tilmicosin, Tylosin and Tiamulin	Enrofloxacin

3. Standardized the GC based analytical techniques for the analysis following pesticides in chicken matrix

Deltamethrin
Chlorpyrifos
Standardized the following in vivo animal models:

Carrageenan induced paw edema in rats
Cotton pellet granuloma is rats
Air pouch granuloma in rats

Adjuvant-induced arthritis in rats
Ehrich ascites carcinoma in mice
Dimethyl hydrazine induced colon cancer in rats
Streptozotocin induced diabetes in rats
Inflammatory Bowel disease model in rats
Hepatotoxicity models in rats

4. Assay protocols standardized

Genotoxicity Assay – AMES, COMET, Micronucleus
Antimicrobial resistance – MIC, ABST, PCR for resistant genes

Faculty

Name of the Faculty	Designation	E-mail	Area of specialization
Dr. S. Ramesh	Professor and Head	ramesh.s@tanuvas.ac.in	Pharmacokinetics, Residue analysis, Laboratory Animal Science
Dr. S. P. Preetha	Assistant Professor	drsppreetha@gmail.com	Cancer Biology, Nanotechnology, Ethnopharmacology
Dr. L. Kalaiselvi	Assistant Professor	kalaiselvivet@gmail.com	Pharmacokinetics, Residue analysis, Anticancer studies
Dr. T. Ramasamy	Assistant Professor	drrams19@gmail.com	Cardiovascular Pharmacology, Antimicrobial resistance

The Professor and Head,
Department of Veterinary Pharmacology and Toxicology,
Madras Veterinary College, Chennai – 600 007.
Phone: +91-44-25304000
E-mail: hodvptmvc@tanuvas.org.in