PRODUCTS PROFILE / TECHNOLOGIES RELEASED

TANUVAS – RUSITEC

Scientists involved

Dr.V. Balakrishnan

Product Technology

An alternative to animal experiments in animal nutrition research have developed indigenously. The technique is called as RUSITEC (Rumen simulation technique) that can replace cattle used in experiments. Since it was developed at Tamil Nadu Veterinary and Animal Sciences University, it is named as TANUVAS – RUSITEC.

Product Presentation  

TANUVAS – RUSITEC consist of

  1. Water bath
  2. Reaction vessel
  3. Perforated cage
  4. Effluent bottle
  5. Gas bag
  6. Saliva tank
  7. Peristaltic pump
  8. Water heater
  9. Control panel.

 

Product Utility  

TANUVAS - RUSITEC is basically an in vitro semi continuous culture system. It simulates heterogeneous rumen under simplified conditions. The apparatus is designed to run continuously and gives the operator maximum control. The inputs as well as the outputs including the gases can be determined using it. Accurately weighed 10 g of feed / fodder to be tested for their nutritive value is placed in the perforated cage along with the inoculum (microbes) from the donor animal (input) in the reaction vessel. The researcher regulates the flow rate of saliva according to the physiological status of the cattle. The amount of solid material that leaves the vessels each day is known as it is taken out manually. The output or the end product of fermentation (VFA, methane and CO2) can be determined from the effluent.

The complete unit has eight reaction vessels, each representing a cow. Thus TANUVAS – RUSITEC is sufficient enough to conduct a valid number of replication to derive meaningful conclusion in research work. High end research for indepth study on intricate aspect of nutrients can be studied through this instrument. TANUVAS – RUSITEC has the following advanced features:

  1. The water bath temperature is controlled effectively through electronic device with allowance to fluctuate only ± 0.5C
  2. Provision to circulate the water in the water bath through heating coil with a automatic cut off, in the event of low level of water. This provision is very handy to prevent electrical short circuit.
  3. Beep indicator alerts the declining level of water.
  4. Peristaltic pump capable of delivering 8 outputs simultaneously through electronically controlled device to facilitate 8 different saliva flow rate. Thus feed/ fodder could be simultaneously evaluated for 8 different physiological statuses with same culture.
  5. Toggle fasteners to secure reaction vessel facilitate easy operation by girls independently.
  6. Compact and occupies less desk space

TANUVAS - RUSITEC would cater the needs of research laboratories involved in conducting nutritional research in ruminants, Pharmaceutical companies engaged in research and development, Analytical laboratories attached to feed industry.

For further details contact

Professor and Head,
Department of Animal Nutrition ,
Madras Veterinary College,
Chennai  600 007
drbalakrishnanphd@yahoo.co.in

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Monoclonal antibody based progesterone assay for early pregnancy diagnosis in cattle

Name of the Product Monoclonal antibody based progesterone assay for early pregnancy diagnosis in cattle
Scientists developed Dr. V. Thiagarajan
Dr. V.D. Padmanaban
Product technology

Development of monoclonal antibody to reproductive hormone progesterone and estimation of the hormone in the milk using the Mabs in Dipstick ELISA and Latex Agglutination Test to detect the pregnancy / non pregnancy status of cows.
Product presentation

Dipstick ELISA
* Progesterone monoclonal antibody 
* Progesterone labeled HRPO
* Nitrocellulose membrane 

LAT  
* Latex beads coated with progesteroneMabs
Product Utility Progesterone assay is to be done on milk samples collected from lactating cows from 21 to 24 days post breeding.The pregnancy/non pregnancy status of the animal will be identified around 24 days after breeding. The accuracy of the test is 100% in detecting non-pregnancy and 80-90% pregnant cows. 
For further details contact Dept. of Animal Biotechnology, 
Madras Veterinary College, 
Chennai - 600 007., 
TANUVAS

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Cryopreserved Hamster Oocyte for Sperm in-vitro Fertility Test

Scientists involved  

Dr.B.P.Brahmkshri
Dr.Thilak Pon Jawahar
Dr.M.John Edwin
Dr.K.S.Raman

Product Technology  


Hamster oocyte is unique in that, its zona free state can be penetrated by spermatozoa of several species depending up on the fertility potential of the sperm tested. The golden hamsters are superovulated, oocytes collected, cryopreserved at –196°C for long time storage. This forms ready availability of oocytes for sperm penetration bioassay.

Product Presentation

Twenty oocytes are packed in French mini straws, stored at –196°C in LN2 and supplied.

Product Utility

* Sperms of different species can be tested viz., Human,Bull, Buffalo, goat, sheep, pig, horse and poultry.
* Useful in periodic monitoring of fertility status of bulls used in Semen Bank for AI program. 
* Human IVF laboratory can employ this test for screening the donors in Assisted Reproductive Technology.
* This test can form a part of quality control test in semen 
production laboratories.

For further details contact  

Semen Bank
Department of Animal Genetics and Breeding 
Madras Veterinary College 
Chennai – 600 007. 

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Bluetongue – AGID Kit

Scientists involved

Dr.A.Koteeswaran
Dr.T.G.Prabakar
Dr.T.V.Meenambigai

Product Technology

Diagnostic kit for detection of Bluetongue antigen and antibody 

Product Presentation

The kit consisting of Lyophilized Bluetongue antigen and Bluetongue antibody (1ml each) 
Agarose – 1g
Phosphate buffered saline (2ml)

Product Utility  

Bluetongue (BT) is a disease of economic importance of sheep and goats. BT caused large scale mortality in southern districts of Tamil Nadu during 1998. The disease should be diagnosed at the earliest for effecting control measures. Hence a diagnostic kit for detection of BTV antibody was developed at TANUVAS. Tests for BTV antibody can be done at field level laboratories using this kit. Purified BTV antigen can also be detected using this kit.

For further details contact

Vaccine Research Centre Viral Vaccines, Centre for Animal Health Studies, MMC, Chennai – 51. 

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Black Quarter (Clostridium chauvoei) vaccine (Improved)

Scientists involved  

Dr.V.Ramasamy
Dr.M.Joseph Andrew Jesudass
Dr.J.John Kirupakaran
Dr.G.Ravikumar
Dr.N.Latha

Product Technology

Clostridium chauvoei strain No. 49 has been used for vaccine production.It was improved for its core antigens and an alum precipitated Black Quarter whole culture vaccine was prepared as per FAO norms.

Product Presentation

Alum precipitated Black Quarter (Clostridium chauvoei) vaccine in 30ml, 50ml and 100ml bottles.

Product Utility

Used for vaccinating cattle, sheep and goats against Black quarter.
Dose : Cattle - 2ml s/c
Sheep and goats - 1ml s/c

For further details contact

Centre of Animal Health Studies,
Madhavaram Milk Colony,
Chennai - 600 051.

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Dietetic Ice cream

Scientists involved 

Dr.K.V.K.Veereswaran
Dr.C.Nareshkumar

Product Technology  

30% replacement of milk fat (cream) with rice branoi

Product Presentation 

50 / 100 ml. Cups reduction in cost

Product Utility 

For diet conscious people as rice bran oil has hypocholestraemic effect.

For further details contact

Department of Dairy Science,
Madras Veterinary College,
Chennai - 600 007.

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Freeze dried culture (Lactobacillus delbrueckii ssp. bulgaricus)

Scientists involved

Dr.B.Dhanalakshmi
Dr.C.Nareshkumar

Product Technology

Freeze-drying.

Product Presentation

Capsules stored at refrigeration temperature.

Product Utility

Preparation of fermented milk product. It is a probiotic culture.

For further details contact

Professor and Head,
Department of Dairy Science,
Madras Veterinary College,
Chennai - 600 007.

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Cured and Smoked Chicken

Scientists involved

Dr.B.Chandrasekar
Dr.K.T.Radhakrishnan

Product Technology

Spent broilers were utilised for the preparation of cured and smoked chicken. Curing mixture consisting of purified salt, cane sugar and sodium nitrate were applied by rubbing thoroughly over the dressed chicken carcass. The cured carcass was stored in a domestic refrigerator for 24 hours for curing. Subsequent to curing the cured carcass was desalinated in warm water for 1 hour. The carcass was smoked for 12 hours at 55° to 60° C. Later the product was allowed to age at refrigerator temperature for 24 hours.

Product Presentation  

The cured and smoked chicken is carved into different joints. These joints are further sliced and served after frying. 

Product Utility  

The marketing of culled birds has been causing a problem in the economic maintenance of large commercial poultry farmers. To over come this problem poultry meat can be cured and smoked to extend its shelf life. This process also facilities easy handling and transportation from production centre to areas of consumption. Such product helps the farmer to enhance the value of the culled chicken. 

For further details contact

Department of Meat Science and Technology,
Madras Veterinary College,
Chennai – 600 007 

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Chicken Sausage

Scientists involved

Dr.K.T.Radhakrishnan
Dr.V.Venkataramanujam

Product Technology  

Chicken meat and fat from culled birds were utilised for the preparation of sausages. Meat was minced separately in a meat mincer and fat was added at the time of emulsion preparation. Dry cure method was adopted with salt, sugar, potassium nitrate, Ascorbic acid and Onion with rusk. The emulsion was prepared and stored for 24 hours at refrigerator temperature. The emulsion was stuffed into wet sheep casings. The stuffed product was smoked at a temperature of 45° to 50° C for 2 hours. The smoked product was cooled and aged at refrigerator temperature for 24 hours. Then the product was cooked at 80° C for 2 hours in a hot air oven. The cooked product was cooled and stored at 8° to 10° C.

Product Presentation

The chicken sausage can be presented as hot dogs, sandwiches, salads and also consumed after frying.

Product Utility  

The advent of broiler industry has rendered the marketing of culled birds difficult in view of the toughness of their meat. Such chicken meat can be conveniently converted into value added poultry meat product such as chicken sausages and marketed. The present consumer demand for processed meat foods can be fulfilled by popularisation of this product 

For further details contact

Department of Meat Science and Technology, 
Madras Veterinary College, 
Chennai - 600 007. 

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Chicken Patties

Scientists involved

Dr.K.K.Aravindan
Dr.G.Thulasi

Product Technology

Chicken meat obtained from culled birds was minced in a meat Mincer and the curing mixture (comprising of salt, sugar, Potassium nitrate and Ascorbic acid) was applied thoroughly by hand rubbing. The chicken meat was cured for 24 hours in a domestic refrigerator. The cured meat was chopped with slushed ice, extending material (defatted soy flour), preminced condiments (pepper, coriander, mace and cinnamon), flavouring agents (garlic, onion and ginger). The emulsion was then moulded into round shaped patties. The prepared patties was cooked by dry heat in a baking oven to reach an internal temperature of 72° C. The cooked patties was stored in a freezer at -18°± 2° C.

Product Presentation  

The chicken patties can be presented as sandwiches, 
salads and also consumed after frying.

Product Utility

Processed meat products are becoming popular now-a-days due to the changes in socio-economical status of the consumers. Patty is one of the comminuted value added and convenience meat products. By popularizing this product, the present consumers' demand for processed meat foods can be fulfilled.

For further details contact

Department of Meat Science and Technology, 
Madras Veterinary College, 
Chennai - 600 007. 

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Live attenuated Peste des Petits Ruminants (PPR) vaccine

Scientists involved

Dr.K.S.Palaniswami 
Dr.A.Thangavelu
Dr.A.Koteeswaran
Dr. K. Saravanabava
Dr.K.Nachimuthu

Product Technology  

Live PPR virus adapted and attenuated in vero cells by serial passage for 75 times. 

Product Presentation  

Vaccine : Freeze dried in a glass vial (50 doses)
Diluent : 50 ml in a polypropylene bottle.

Product Utility  

PPR is an acute, highly contagious and fatal rinderpest like disease of small ruminants and in unprotected animals the mortality may reach 60-70%. PPR virus first reported in India in 1987 from an outbreak in Tamil Nadu and since then the disease was reported from all over the country. The use of rinderpest vaccine to protect small ruminants against PPR is contraindicated because its use induces antibodies to rinderpest, which compromises sero-surveillance for rinderpest. Hence the present vaccine was developed for control of PPR in sheep and goats. It is used for prophylatic vaccination against PPR in sheep and goats.

For further details contact

Department of Microbiology, 
Madras Veterinary College, 
TANUVAS, 
Chennai – 600 007.

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Oral Pellet Vaccine for Newcastle Disease

Scientists involved

Dr.J.John Kirupakaran
Dr.K.S.Palaniswami

Product Technology 

Lactose pellet technology using thermostabilised Newcastle disease virus passaged in embryonated eggs.

Product Presentation  

Vaccine granules in 10 and 20 doses.

Product Utility  

This vaccine contains live D58 isolate of Newcastle disease virus in pellets made up of lactose, starch and amaranthus dye. It can be used for prophylactic vaccination against Newcastle disease. This vaccine is mainly meant for village chickens, which act as source of virus spread to commercial poultry.

For further details contact

Department of Microbiology, 
Madras Veterinary College, 
Chennai – 600 007

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Single Radial Immuno Diffusion (SRID) KIT

Scientists involved  

Dr.G.Dhinakar Raj
Dr.K.Nachimuthu

Product Technology  

Estimation of antibody levels in the serum of newborn calves using single radial immuno-diffusion (SRID) technique.

Product Presentation  

1) Freeze dried buffalo IgG standard and anti serum to it.
2) Chemicals for gel preparation

Product Utility  

This kit is useful to identify calves (especially buffalo calves) with failure of passive transfer. Serum IgG values less than 800mg/dl in calves 24 - 48 hrs after birth clearly indicates that those calves are prone to neonatal calf mortality.

For further details contact

Dept. of Animal Biotechnology
Madras Veterinary College, 
Chennai - 600 007.

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Monoclonal antibody based LATEX AGGLUTINATION TEST for Diagnosis of Blue Tongue in sheep

Scientists involved  

Dr. G. Dhinakar Raj
Dr. V. Thiyagarajan 
Dr. K. Nachimuthu

Product Technology

Monoclonal antibodies against Blue Tongue Virus has been developed. Latex beads sensitized with these Mab are used to detect Blue Tongue Viral antigen

Product Presentation

Latex beads coated with BTV Mabs

Product Utility

Diagnosis of Blue Tongue in Sheep

For further details contact

Dept. of Animal Biotechnology 
Madras Veterinary College 
Chennai - 600 007

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Inactivated Newcastle disease virus vaccine

Scientists involved

Dr. V.D. Padmanaban
Dr. K. Kumanan
Dr. K.Nachimuthu
Dr. Daniel Joy Chandran 

Product Technology  

The vaccine is prepared using BHK21 adapted velogenic Newcastle disease virus. The vaccine seed virus has been passaged 41 times in BHK21 cells. The following is the flow chart for vaccine production - Propagation of seed virus in BHK21 cells in fermentors Õ Harvesting the vaccine virus Õ Concentration of the vaccine virus using vaccine concentrator Õ Inactivation of the vaccine virus using formalin Õ Mixing the vaccine virus with Aluminium Hydroxide gel Õ Bottling and labeling, Sterility, Safety and Potency testing

Product Presentation  

As 50 or 100 doses vials

Product Utility

All the currently available vaccines are being produced in embryonated chicken eggs and internationally it is advised to use Specific Pathogen Free embryos (SPF) for vaccine production. However the use of SPF eggs for vaccine production is likely to increase the cost of vaccine at least 30 times more than the ordinary embryos and further SPF eggs are not freely available in this country currently. The current vaccine has been adapted to BHK21 cellline, a mammalian cellline, which will not permit adventious poultry pathogens. Moreover, bulk antigen production using fermenters is possible using BHK21 cells which are anchorage independent

For further details contact

Department of Animal Biotechnology
Madras Veterinary College
Chennai-600 007

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Live attenuated Peste des Petits Ruminants (PPR) vaccine - TN/97 strain

Scientists involved

Dr. G. Dhinakar Raj
Dr. K. Nachimuthu 
Dr. K.S. Palaniswami

Product Technology



PPR Vaccine - TN/97

strain Field isolate of PPR virus adapted and attenuated in Vero cells by serial passage for 75 times

Product Presentation  

Vaccine : Freeze dried as 50 doses vials
Diluent : 50 ml in a polypropylene bottle

Product Utility

The vaccine is useful to protect sheep and goats against PPR

For further details contact

Dept. of Animal Biotechnology
Madras Veterinary College 
Chennai - 600 007

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Trivalent Leptospira (inactivated) vaccine for bovines

Scientists involved  

Dr. K.S. Venkataraman
Dr. R. Manickam

Product Technology

Development of a trivalent Leptospira (inactivated) vaccine for bovines incorporating the three Leptospiral serovars viz. Pomona, hardjoand grippotyphosa. The vaccine is Thiomersal inactivated, aluminum hydroxide gel absorbed vaccine to confer specific immunity against Leptospirosis in cattle

Product Presentation  

30 ml (5 doses)6 ml (Single Dose)

Product Utility

The vaccine prevents leptospiral abortion, infertility, still birth and loss of milk production.It helps in the prevention of transmission of the disease from cattle to other livestock and human beings

For further details contact

The Associate Professor and Head
Leptospirosis Research Laboratory 
Centre for Animal Health Studies
TANUVAS
Madhavaram Milk Colony
Chennai-600 051

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Insulation bag for transport of Catamaran shrimp catch

Scientists involved  

Dr. K. Rathnakumar 
Thiru S.A.Shanmugam
Dr. P. Velayutham

Product Technology  

The design and the fabrication of insulated bag was based on the performance of insulation material, ice keeping capacity and suggestion of fishermen. Ice retention capacity of the bag after 10 hours was 62%. During the study it was found that initial temperature of +2oC increased to 10oC after adding equal volume of shrimps (10 kg). This again came down to +2 oC after one hour. At the end of 12 hours, temperature of iced shrimp was 8oC. This 12 hours period is sufficient for catamaran fishermen to complete their fishing trips. From the field study conducted covering 60 fishing days, it was found that zero percent spoilage was observed when the shrimp caught were transported in insulated bag with Ice, whereas in the uniced condition, spoilage was found to be 7-8% of the total catch

Product Presentation 

Fabricated bag has an innermost layer of aluminium sheet and one inch thickness of thermocole was placed in between the stitched laminated tarpauline. This Box is placed in a tarpauline bag having nylon handle on two sides. The inner dimesion of the bag is 30x30x30 cm (BxHxT) and the outer dimesion in 32.5x32.5x32.5 (BxHxT)

Product Utility 

As the holding capacity of the bag in 24 kg, it will conveniently hold 10 kg of fresh shrimp and 10 kg of Ice. This bag protect the shrimp against contamination, losses due to spoilage and also make it easier and safer to transport immediately after catch

For further details contact

The Dean
Department of Fish Processing Technology
Fisheries College and Research Institute
Thoothukudi - 628 008

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Enriched Paddy Straw Blocks

Scientists involved  

Dr. Berty Edwin 
Dr. M. Murugan

Product Technology  

The physical and chemical evaluations of the blocks were done as per standard procedures available in literature

Product Presentation

Block of size 30x30x10 cm weighing approximately 1 kg

Product Utility  

The enriched paddy straw when compacted into high-density blocks along with essential nutrients will be an economic feed for low yielding milch animals. Further the straw can be made readily available with minimal transportation cost

For further details contact

The Professor and Head
Institute of Animal Nutrition
Kattupakkam
Chennai - 603 203

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Inactivated oil emulsion Infectious Bursal Disease Virus vaccine (TC origin)


Scientists involved  

Dr. A. Thangavelu 
Dr. K.S. Palaniswami
Dr. V. Purushothaman

Product Technology



Incativated IBD Vaccine

Cell grown IBDV, inactivated with BEI and oil adjuvanted with Montanide

Product Presentation  

Oil emulsion vaccine in multidose plastic bottle

Product Utility  

The vaccine is used for prophylaxis against IBD. Unprimed birds are vaccinated at 1 week of age. The Vaccine affords protection upto 10 weeks of age. This vaccine can be used as booster for the birds previously primed with live vaccine, at any time after 14 days

For further details contact

The Professor and Head
Department of Microbiology 
Madras Veterinary College 
Chennai - 600 007

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Live attenuated Peste des Petits Ruminants (PPR) thermostable vaccine" (TN MIB /87)

Scientists involved  

Dr.K.S.Palaniswami
Dr.A.Thangavelu
Mr.R.Velmurugan

Product Technology  

Live PPR virus serially passaged and simultaneously selected in higher temperature in vero cells

Product Presentation 

Vaccine : Freeze dried in a glass vial (50 doses)
Diluent : 50 ml in a polypropylene bottle 

Product Utility

PPR is an acute, highly contagious and fatal rinderpest like disease of small ruminants and in unprotected animals the mortality may reach 60-70%. PPR virus first reported in India in 1987 from an outbreak in Tamil Nadu and since then the disease was reported from all over the country. The use of rinderpest vaccine to protect small ruminants against PPR is contraindicated because its use induces antibodies to rinderpest, which compromises sero-surveillance for rinderpest. Hence the present vaccine was developed for control of PPR in sheep and goats which is stable at room temperature and doesn't require cold chain. Stability at 37oC temperature for 21 days confirmed.It is used for prophylatic vaccination against PPR in sheep and goats

For further details contact

Department of Microbiology 
Madras Veterinary College 
Chennai - 600 007

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Neats Foot Oil Ointment

Scientists involved

Dr. K.V.S. Naryana Raju
Dr. V.V. Kulkarni
Dr. N. Punniamurthy

Product Technology

This Ointment is prepared by adding Neats Foot Oil, extracted from the feet (last two phalanges) of cattle, buffalo, sheep and goats by a process of wet rendering at a pressure level of 15 PSI for 4 hours and purified with normal saline and acetone and filtered at a level of 20% in paraffin base. The consistency of the ointment should be homogenous and smooth

Product Presentation  

Neats foot oil ointment is semi solid product and can be stored in amber coloured glass / plastic containers for better shelf life 

Product Utility

The raw material is abundantly available at a comparatively low cost. The keeping quality of the oil is good. The ointment prepared will also be cheap and effective in healing the wounds

For further details contact

The Professor and Head 
Department of Meat Science and Technology
Veterinary College and Research Institute
Namakkal - 637 001

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Neats Foot Oil

Scientists involved

Dr.V.V. Kulkarni
Dr. K. Sivakumar
Dr. Robinson J.J. Abraham

Product Technology

Neats Foot Oil is extracted from the feet (last two phalanges) of cattle, buffalo, sheep and goats by a process of wet rendering at a pressure level of 15 PSI for 4 hours. Crude oil is purified with normal saline and acetone and filtered 

Product Presentation  

Neats foot oil is liquid at room temperature and can be stored in amber coloured glass / plastic containers for better shelf life 

Product Utility  

Neats foot oil has a wide range of applications such as in ointment preparation in wound healing, lubricant in delicate machinery, fat liquoring agent in finishing of leather and oil adjuvants in injectable pharmaceutical preparations. The purified and fractioned neats foot oil has a very low solidification point below -10oC, and hence it can be used in specific machinery

For further details contact

The Professor and Head
Department of Meat Science and Technology
Veterinary College and Research Institute 
Namakkal - 637 001

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