VACCINE RESEARCH CENTRE - VIRAL VACCINE

Vaccine Research Centre – Viral Vaccines was started on 10th October 1983 for conducting research and development on the vaccines and diagnostics for the important and emerging viral diseases affecting livestock and poultry. VRCVV is located in Madhavaram Milk Colony since 1995. It is one of the constituent units of the Centre for Animal Health Studies, TANUVAS, as a plan scheme of the Government of Tamil Nadu.

Objectives

  • Development of cost effective vaccines to cater to the needs of farmers and livestock breeders and to improve the quality of existing vaccines
  • Development of field level diagnostic kits for rapid identification of causative agent
  • Development of conventional vaccines for the control of emerging poultry diseases
  • Establishment of Centre of Excellence in Veterinary Viral Vaccinology
  • Disease investigation of the viral diseases affecting the livestock and poultry
  • Education and training of students, field veterinarians and personnel from industry in the diagnosis and control of viral diseases affecting the livestock and poultry
  • Awareness programmes for the farmers on the diagnosis and control of viral diseases affecting the livestock and poultry
  • Internal validation of vaccines developed by the departments of TANUVAS

Laboratory Facilities

  • The Cell Culture Laboratory is being utilized for the propagation of viruses and for development of vaccines for important poultry and livestock diseases.
  • The Serology Laboratory facilitates for the sero monitoring and sero diagnosis of important poultry and livestock diseases.
  • The Molecular Virology Laboratory facilitates for the molecular characterization of vaccine and field viruses and also for the molecular epidemiological studies of the viruses.
  • Identification facility for bluetongue virus vector, Culicoides.

Research Schemes Completed

Externally funded schemes

  • National
    • SERB, DST funded scheme on, “Development of Diagnostic Tools and Vaccine for Porcine Circovirus 2, an Emerging Pathogen”.
    • NAIP scheme on “Toll-Like Receptors in Phylogenetically Divergent Fish Species and their Contribution in Modulation the Innate Immunity” as Co-centre.
    • DST scheme on “Identification and Assessment of the Expression Profiles of Important Toll-Like Receptors (TLRs) in Commercially Important Food and Ornamental fishes”.
    • DBT Scheme on “Development of Molecular and Immunodiagnostic Kits for Hepatopancreatic Parvovirus (HPV) in Shrimp”.
    • NADP Scheme Component 4 (Sheep pox) on “Development of Multiplex PCR assay and Flow Through Membrane Assay”.
    • ICAR funded scheme on “Antigenic, pathogenic and Molecular Characterization of Field isolates of Infectious Bursal Disease Virus”.
    • ICAR funded scheme on “Development of a Homologous vaccine for Contagious Ecthyma”.
    • National project on Rinderpest Eradication funded scheme on “Development of a Homologous vaccine for Peste des petits ruminants”.
    • Board of Research on Nuclear Sciences, Government of India funded scheme on “Molecular Characterization of polypeptides of Rinderpest and PPR viruses”.
  • International
    • SEPPIC, France and its Indian affiliate Yasham Specialty Ingredients Pvt Ltd, Mumbai funded project on “Large Scale Field Testing of Inactivated Multivalent Adjuvanted Vaccine for Bluetongue”.
    • Indo UK BBSRC funded project on “Monitoring and Intervention Strategies for Bluetongue Virus Epidemics in Rural India”.
    • Seppic , France and its Indian affiliate Yasham Biosciences Pvt. Ltd. funded collaborative project on “Development of Efficacious Inactivated Newcastle Disease Virus Vaccine.”
  • Government of Tamil Nadu Schemes
    1. Development of inactivated swine fever virus vaccine
    2. Development of cell culture based vaccine for sheep pox
    3. Studies on Chicken anaemia virus
    4. Simultaneous antibody screening to three major poultry diseases
    5. Development of Bluetongue diagnostic kit
    6. Scheme on strengthening the Vaccine Research Centre – Viral Vaccines for molecular epidemiology
    7. Development of Bluetongue vaccine for sheep 8. Assessment of physical and microbiological score for evolving standards for chick quality
  • Self-financing scheme
    • Production and supply of biologicals, diagnostic reagents and for diagnostic services
    • Shrimp Disease Diagnostic Laboratory (Transferred to Tamil Nadu Fisheries University)

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Ongoing Research Schemes

Externally funded schemes

  • National
    • ICAR funded "All India Net Work Programme on bluetongue" TANUVAS Centre
    • ICAR funded “National Centre for Veterinary Type Cultures Network Project TANUVAS Unit” TANUVAS Centre with Tribal Sub-plan Programme.
  • Government of Tamil Nadu Schemes
    • Plan scheme on “Establishment of Vaccine Research Centre - Viral Vaccines”
    • TANII project on “One Health approach for Animal and Public Health to Augment Food Safety and Productivity” as participating unit

Workshops/Training programmes organized

  • National level workshop on Bluetongue vector identification from 02.11.2015 to 06.11.2015 • Annual scientist meeting of the ICAR funded All India Network Programme on Bluetongue on 02.11.2015.
  • ASCAD workshop on Bluetongue diagnosis and control on 17.11.2015 to 75 veterinarians from the Department of Animal Husbandry, Tamil Nadu.
  • ASCAD training programme on Diagnostic assays for detection of bovine viral diseases during 2015 to 22 veterinarians from the Department of Animal Husbandry, Tamil Nadu.
  • International programme on Stake holders meeting of Bluetongue risk assessment was held at the Institute of Animal health and Veterinary Biologicals, Hebbal, Bangalore from 20.05.2014 to 21.05.2014. The programme was jointly organized by Indo-UK project, IBV Net centres of Hisar, TANUVAS, SVVU, IAHVB and the UK collaborator from Centre for Ecology and Hydrology, Oxford, UK. Veterinary officers from Tamil Nadu, Karnataka and Andhra Pradesh participated in the programme
  • The International Training Programme on Bluetongue vector identification during 01.07.2013 to 05.07.2013. The Programme was funded by Biotechnology and Biological Sciences Research Council (BBSRC), UK as part of the ongoing UK-India collaborative project 'Monitoring and Intervention strategies for Bluetongue virus epidemics in rural India'
  • ASCAD specialized training on the diagnosis of viral diseases of Ruminants to Veterinary Assistant Surgeons in the Animal disease intelligence units from Dept. of Animal Husbandry, Tamil Nadu from 11.06.2013 to 30.07.2013.
  • ASCAD training on Tissue Culture Techniques and Virus Isolation to Veterinary Assistant Surgeons from Dept. of Animal Husbandry from 5-3-2013 to 18-3-2013
  • Annual scientist meeting of the ICAR funded All India Network Programme on Bluetongue from 04.05.2010 to 05.05.2010.
  • Training on Animal Tissue Culture to life science undergraduate students, postgraduate students and faculty members of Universities on need basis.

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Vaccines Developed

  • Inactivated Infectious bursal disease Virus Vaccine
  • Inactivated Hydropericardium Syndrome Vaccine
  • Inactivated Ranikhet Disease Virus Vaccine
  • Adjuvant for Ranikhet disease virus live vaccine
  • Inactivated Classical Swine Fever vaccine
  • Bluetongue multivalent inactivated vaccine
Inactivated Infectious Bursal
Disease Virus Vaccine
Inactivated Hydropericardium
Syndrome Vaccine
Inactivated Ranikhet Disease
Virus Vaccine

Diagnostic Kits Developed

  • Infectious bursal disease Agar gel immunodiffusion test kit
  • Ranikhet disease virus haemagglutination inhibition test kit

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Commercialization of the Technology

  • The technology of Bluetongue Multivalent Inactivated Adjuvanted Vaccine was transferred to four animal vaccine companies during 2011 - 17 and the vaccine is available commercially. M/s Biovet Private Limited, which has received the BTV vaccine technology, was awarded with Technology Day Award during 2013 by the President of India in recognition of the efforts of the company to commercialize the vaccine.
Bluetongue trivalent vaccine release 2005 Bluetongue multivalent inactivated vaccine developed at TANUVAS
BT Vaccine transfer of Technology to four Animal vaccine companies (2011-2017)
Commercial launch of BT vaccine (08.01.2015) National Award 2013 for commercialization of the Bluetongue Vaccine

Establishment of Culicoides sps identification facility

Established collaboration with UK laboratories such as London School of Hygiene and Tropical Medicine, Rothamsted Research and Centre for Ecology and Hydrology and the Pirbright Institute Logistics for the collection and identification of Culicoides Sps. have been developed and at VRCVV, the facility for identification of the Culicoides of livestock importance has been established for the first time in India.

International BT vector training programme July, 2013 Interaction with Dr. Tim Leyland, Consultant, BBSRC- UK

 

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Faculty

Dr. Y.Krishnamohan Reddy, Professor and Head | drykmreddy@hotmail.com; kmreddy.y@tanuvas.ac.in
Dr. A.Ramesh | Professor | Email:ramesh.a@tanuvas.ac.in
Dr. S.Rathnapraba, Associate Professor | rathnapraba.s@tanuvas.ac.in
Dr. K.Anbu Kumar, Assistant Professor | anbukumar.k@tanuvas.ac.in

Contact

Professor and Head
Vaccine Research Centre-Viral Vaccines,
Centre for Animal Health Studies
Tamil Nadu Veterinary and Animal Sciences University
Madhavaram Milk Colony, Chennai – 600 051
Telephone : 0091(0)44 25551573 | Mobile: 00919962754861
FAX : 044-25551577 | E Mail: vrcvv@tanuvas.org.in