TANUVAS
Bio containment Animal Disease Laboratory
(TANUVAS-BCADL)

Introduction

A biosafety level is a set of biocontainment precautions required to isolate and assay dangerous biological agents in an enclosed laboratory facility. The levels of containment range from the lowest biosafety level 1 (BSL-1) to the highest at level 4 (BSL-4). The levels are designated in ascending order, by degree of protection provided to personnel, environment and community. Special microbiological practices enhance worker safety, environmental protection and address the risk of handling agents requiring increasing levels of containment.

BSL - 3 Laboratory

Biosafety level 3 facility is commonly used for research and diagnostic work involving various microbes which can be transmitted by aerosols and / or cause severe disease in human / animals.

TANUVAS - BCADL

  • TANUVAS is establishing a unique facility namely, "Biosafety level-3 (BSL 3) Laboratory with Small Animal Experimentation Facility" through funding from Tamil Nadu Innovation Initiatives (TANII) of the Govt. of Tamil Nadu. This project is being implemented on a turn-key basis by the National Dairy Development Board, Anand, Gujarat. This facility is likely to be commissioned by the end of November 2018. This is probably the ‘first-of-its-kind’ facility in a State run Veterinary University in India.

Objectives

  • To undertake diagnostic services for identified BSL-3 viral and bacterial pathogens, subject to required regulatory approvals.
  • To undertake research on identified BSL-3 viral and bacterial pathogens including animal trials, subject to required regulatory approvals.
  • To undertake regulatory quality assurance services for vaccine / drug manufacturers.
  • Capacity building in the area of biosafety applications for students, researchers and stake holders

Facility Description

  • The BSL-3 laboratory has an overall foot print of 2835 sq ft (63 ft x 45 ft).
  • The core laboratory consists of two units namely,
  • Virology laboratory – 378 sq ft (21 ft x 18 ft)
  • Animal experimentation unit – 558 sq ft (31 ft x 18 ft)
  • The remaining 1800 sq ft area includes service areas such as shower entry areas, airlocks, corridors, effluent treatment areas etc.,

TANUVAS - BCADL - Animal experimentation unit

  • The animal experimentation unit is designed to handle the following species of animals
    • Rodents (Rat, Mice and Guinea Pig)
    • Poultry species (chicken, quail and duck)
  • Individually ventilated caging system is available for conducting experiments on laboratory rodents under biocontainment.
  • Experiments can be conducted in 100 rats or 100 mice or 40 guinea pigs at a time.
  • Experiments can be conducted on 40 birds (in two groups) using chicken isolators.

Few pathogens that can be handled in this laboratory (subject to regulatory approval)

  • Foot-and-mouth disease virus (Molecular/ Sero diagnosis only)
  • Avian influenza virus (Molecular/ Sero diagnosis only)
  • Swine influenza virus (Molecular/ Sero diagnosis only)
  • Rabies virus
  • Nipah virus (Molecular/ Sero diagnosis only)
  • Brucella species (all type of research/ diagnostic work)
  • Anthrax (all type of research/ diagnostic work)

Potential users of TANUVAS - BCADL

  • Biological / Vaccine manufacturers
  • National / State regulators for testing
  • State / Central Government laboratories and isntitutions • In-house research

How to utilize TANUVAS - BCADL

The interested institutions / researchers may send an expression of interest (EoI) for utilizing the facility by providing information on the nature of work to be carried out, pathogens to be handled, duration of the study, experimental animals involved, sampling of animals etc. TANUVAS - BCADL will provide details about the costing and terms and conditions for utilizing this facility on a case-to-case basis.

For further details contact

The Director, Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram Milk Colony, Chennai-600 051 Phone No.: 044 – 25555151; Mobile: 91-9381036277; e-mail: dcahs@tanuvas.org.in, bsl3lab@tanuvas.org.in